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Posted by: thepinetree on 11/13/2021 10:36 AM Updated by: thepinetree on 11/13/2021 10:36 AM
Expires: 01/01/2026 12:00 AM
:

‘Dancing Molecules’ Successfully Repair Severe Spinal Cord Injuries

Evanston, IL....Northwestern University researchers have developed a new injectable therapy that harnesses “dancing molecules” to reverse paralysis and repair tissue after severe spinal cord injuries.  In a new study, researchers administered a single injection to tissues surrounding the spinal cords of paralyzed mice. Just four weeks later, the animals regained the ability to walk.






The research was published in the Nov. 12 issue of the journal Science.  The study is available online.


By sending bioactive signals to trigger cells to repair and regenerate, the breakthrough therapy dramatically improved severely injured spinal cords in five key ways: (1) The severed extensions of neurons, called axons, regenerated; (2) scar tissue, which can create a physical barrier to regeneration and repair, significantly diminished; (3) myelin, the insulating layer of axons that is important in transmitting electrical signals efficiently, reformed around cells; (4) functional blood vessels formed to deliver nutrients to cells at the injury site; and (5) more motor neurons survived.

After the therapy performs its function, the materials biodegrade into nutrients for the cells within 12 weeks and then completely disappear from the body without noticeable side effects. This is the first study in which researchers controlled the collective motion of molecules through changes in chemical structure to increase a therapeutic’s efficacy.

“Our research aims to find a therapy that can prevent individuals from becoming paralyzed after major trauma or disease,” said Northwestern’s Samuel I. Stupp, who led the study. “For decades, this has remained a major challenge for scientists because our body’s central nervous system, which includes the brain and spinal cord, does not have any significant capacity to repair itself after injury or after the onset of a degenerative disease. We are going straight to the FDA to start the process of getting this new therapy approved for use in human patients, who currently have very few treatment options.”

Stupp is Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering at Northwestern, where he is founding director of the Simpson Querrey Institute for BioNanotechnology (SQI) and its affiliated research center, the Center for Regenerative Nanomedicine. He has appointments in the McCormick School of EngineeringWeinberg College of Arts and Sciences and Feinberg School of Medicine.

Life expectancy has not improved since the 1980s

According to the National Spinal Cord Injury Statistical Center, nearly 300,000 people are currently living with a spinal cord injury in the United States. Life for these patients can be extraordinarily difficult. Less than 3% of people with complete injury ever recover basic physical functions. And approximately 30% are re-hospitalized at least once during any given year after the initial injury, costing millions of dollars in average lifetime health care costs per patient. Life expectancy for people with spinal cord injuries is significantly lower than people without spinal cord injuries and has not improved since the 1980s.

“Currently, there are no therapeutics that trigger spinal cord regeneration,” said Stupp, an expert in regenerative medicine. “I wanted to make a difference on the outcomes of spinal cord injury and to tackle this problem, given the tremendous impact it could have on the lives of patients. Also, new science to address spinal cord injury could have impact on strategies for neurodegenerative diseases and stroke.”

‘Dancing molecules’ hit moving targets

The secret behind Stupp’s new breakthrough therapeutic is tuning the motion of molecules, so they can find and properly engage constantly moving cellular receptors. Injected as a liquid, the therapy immediately gels into a complex network of nanofibers that mimic the extracellular matrix of the spinal cord. By matching the matrix’s structure, mimicking the motion of biological molecules and incorporating signals for receptors, the synthetic materials are able to communicate with cells.

“Receptors in neurons and other cells constantly move around,” Stupp said. “The key innovation in our research, which has never been done before, is to control the collective motion of more than 100,000 molecules within our nanofibers. By making the molecules move, ‘dance’ or even leap temporarily out of these structures, known as supramolecular polymers, they are able to connect more effectively with receptors.”

Stupp and his team found that fine-tuning the molecules’ motion within the nanofiber network to make them more agile resulted in greater therapeutic efficacy in paralyzed mice. They also confirmed that formulations of their therapy with enhanced molecular motion performed better during in vitro tests with human cells, indicating increased bioactivity and cellular signaling.

“Given that cells themselves and their receptors are in constant motion, you can imagine that molecules moving more rapidly would encounter these receptors more often,” Stupp said. “If the molecules are sluggish and not as ‘social,’ they may never come into contact with the cells.”

One injection, two signals

Once connected to the receptors, the moving molecules trigger two cascading signals, both of which are critical to spinal cord repair. One signal prompts the long tails of neurons in the spinal cord, called axons, to regenerate. Similar to electrical cables, axons send signals between the brain and the rest of the body. Severing or damaging axons can result in the loss of feeling in the body or even paralysis. Repairing axons, on the other hand, increases communication between the body and brain.

The second signal helps neurons survive after injury because it causes other cell types to proliferate, promoting the regrowth of lost blood vessels that feed neurons and critical cells for tissue repair. The therapy also induces myelin to rebuild around axons and reduces glial scarring, which acts as a physical barrier that prevents the spinal cord from healing.

“The signals used in the study mimic the natural proteins that are needed to induce the desired biological responses. However, proteins have extremely short half-lives and are expensive to produce,” said Zaida Álvarez, the study’s first author and former research assistant professor in Stupp’s laboratory. “Our synthetic signals are short, modified peptides that — when bonded together by the thousands — will survive for weeks to deliver bioactivity. The end result is a therapy that is less expensive to produce and lasts much longer.”

Universal application

While the new therapy could be used to prevent paralysis after major trauma (automobile accidents, falls, sports accidents and gunshot wounds) as well as from diseases, Stupp believes the underlying discovery — that “supramolecular motion” is a key factor in bioactivity — can be applied to other therapies and targets.

“The central nervous system tissues we have successfully regenerated in the injured spinal cord are similar to those in the brain affected by stroke and neurodegenerative diseases, such as ALS, Parkinson’s disease and Alzheimer’s disease,” Stupp said. “Beyond that, our fundamental discovery about controlling the motion of molecular assemblies to enhance cell signaling could be applied universally across biomedical targets.”

Other Northwestern study authors include Evangelos Kiskinis, assistant professor of neurology and neuroscience in Feinberg; research technician Feng Chen; postdoctoral researchers Ivan Sasselli, Alberto Ortega and Zois Syrgiannis; and graduate students Alexandra Kolberg-Edelbrock, Ruomeng Qiu and Stacey Chin. Peter Mirau of the Air Force Research Laboratories and Steven Weigand of Argonne National Laboratory also are co-authors.

The study, “Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury,” was supported by the Louis A. Simpson and Kimberly K. Querrey Center for Regenerative Nanomedicine at the Simpson Querrey Institute for BioNanotechnology, the Air Force Research Laboratory (award number FA8650-15-2-5518), National Institute of Neurological Disorders and Stroke and the National Institute on Aging (award numbers R01NS104219, R21NS107761 and R21NS107761-01A1), the Les Turner ALS Foundation, the New York Stem Cell Foundation, the Paralyzed Veterans of America Research Foundation (award number PVA17RF0008), the National Science Foundation and the French Muscular Dystrophy Association.




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No Subject
Posted on: 2021-11-13 11:32:14   By: Anonymous
 

Fuk Trump! Best President in US History! Four More Years of Biden!! Superhero in chief!! Build Back Better!!

Let’s go Joe!


[Reply ]

    Re:
    Posted on: 2021-11-13 11:52:45   By: Anonymous
     
    Jimmy Carter 2.0

    [Reply ]

      Re:
      Posted on: 2021-11-13 12:03:27   By: Anonymous
       
      Jimmy was the worst president ever but now biden showing his true colors Jimmy's the best president ever...

      [Reply ]

    Re:
    Posted on: 2021-11-14 09:02:43   By: Anonymous
     
    Let's go Joe!!!! Wake up Joe... Joe? Nap times over, suit up in your scuba gear.
    🤣😂😂🤣 Yeah let's hope the " SUPERHERO" RUNS FOR REELECTION!!!
    That would be totally AWESOME!!! Especially for the RIGHT THE REPUBLICAN PARTY AND A FREE AMERICA "Biden with a 59% disapproval – more than 21 points underwater. Forty-six percent of those included in the survey said Biden has done a worse job than expected, and 64% said they don't want Biden to run for reelection.

    Harris has just a 27.8% approval rating with 51.2% disapproving of her performance in office, according to USA Today/Suffolk University. That is more than 23 percentage points underwater."
    The SUPERHERO is actually a SCUBA DIVER in real life flopping around in a giant tank of excrement from the asses of all of the socialist in DC.
    Superhero? 😆Looks like some transplant up here wanting free Free FREE has had too many illegal drugs in his pathetic life.


    [Reply ]

No Subject
Posted on: 2021-11-13 11:40:04   By: Anonymous
 
This is an amazing discovery for paralysis.

[Reply ]

No Subject
Posted on: 2021-11-13 11:41:35   By: Anonymous
 
What do you have for dancing molecules to tighten up sniveler's ass hole?...

[Reply ]

    Re:
    Posted on: 2021-11-13 11:44:52   By: Anonymous
     
    Nothing can help sniveler he's reamed out for life, Brian

    [Reply ]

      Re:
      Posted on: 2021-11-13 20:50:53   By: Anonymous
       
      anti sniveler is a frustrated homo.

      [Reply ]

        Re:
        Posted on: 2021-11-14 06:38:21   By: Anonymous
         
        You can dish it out but you can't take it...

        [Reply ]

        Re:
        Posted on: 2021-11-14 09:05:23   By: Anonymous
         
        You ever notice that all anti sniveler talks about is men's dick and a$$holes?
        I
        Either he is a tranny of his dick is so small he had penis envy. I bet the tranny would suck the crime off my trailer hitch.

        [Reply ]

No Subject
Posted on: 2021-11-14 07:10:34   By: Anonymous
 
More people have died of covid 19 under biden than Trump. Fact check sloppy ass hole sniveler...

[Reply ]

    Re:
    Posted on: 2021-11-14 07:34:02   By: Anonymous
     

    More lies coming from the GOP. We all know more people passed away under the fat, disgusting, vile, lying con man Trump then under our awesome amazing superhero in chief President Biden!!

    Let’s go Joe!!! Build Back Better!!


    [Reply ]

      Re:
      Posted on: 2021-11-14 08:42:20   By: Anonymous
       
      joe's the 2021 Jimmy Carter...

      [Reply ]

    Re: fact check
    Posted on: 2021-11-14 08:42:24   By: Anonymous
     
    And the 90+% that have died are unvaccinated.
    Fact. The dotards continue to push their no vaccine policy.
    GOP dotards that don't vaccinate are most likely to die of covid.
    GOP voters will be less in the coming years. Fine with me.
    You can't fix stupid.

    [Reply ]


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